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A new paper has been published.
A new study conducted in collaboration with Drs. Noriyuki Azuma, Hiroshi Nishina, and others at Tokyo Medical and Dental University and National Center for Child Health and Development has been
published in Human Molecular Genetics. This study focused on INTS15, a protein of unknown function that was speculated to be the 15th subunit of Integrator, a giant protein complex that binds to the C-terminal domain of RNA polymerase II. The study revealed that INTS15 indeed functions as a subunit of Integrator, and that INTS15 is important for eye and brain formation, and that a point mutation in the human INTS15 gene causes a dominant developmental ocular anomaly with unique symptoms.