The results of joint research with Dr. Noriyuki Azuma, Dr. Hiroshi Nishina, and colleagues at Tokyo Medical and Dental University and the National Center for Child Health and Development have been published in Human Molecular Genetics, an international journal of human genetics. This research focused on INTS15, a protein of unknown function that was speculated to be the 15th subunit of Integrator, a giant protein complex that binds to the C-terminal domain of RNA polymerase II. The study revealed that INTS15 is important for eye and brain development, and that point mutations in the human INTS15 gene cause a specific symptomatic ocular congenital abnormality with dominant inheritance.