The results of our joint research with Prof. Handa and colleagues at Tokyo Medical University have been published in Scientific Reports. This is the result of a genetic screening to elucidate the mechanism of anticancer activity of thalidomide derivatives against multiple myeloma, and revealed that the subcellular localization of thalidomide target protein cereblon (CRBN) plays […]

The results of our joint research with Prof. Hidetaka Takahashi and colleagues at Yokohama City University have been published in Nature Communications. This study revealed that a central factor for transcription initiation called Mediator and a transcription elongation factor complex called Little Elongation Complex (LEC) are involved in transcription termination of some genes in a

The results of a collaborative study with Tokyo Medical University and others have been published in Nature Chemical Biology. The study identified p63, a transcription factor of the p53 family, as a novel substrate protein for Cereblon (CRBN) E3 ubiquitin ligase, an intracellular target protein of thalidomide, and found that ubiquitination and degradation of the

The results of our joint research with Professor Hiroshi Handa, Tokyo Medical University, have been published in iScience (a new journal from Cell Press). This study reveals a new function of cereblon (CRBN), an intracellular target protein of thalidomide, using zebrafish as a model organism. CRBN regulates the proliferation of neural stem cells. Since CRBN

The results of our joint research with Professor Takaaki Tamura, Graduate School of Science, Chiba University, have been published in Scientific Reports. This study shows that TLP, a member of the TATA box-binding protein family, regulates the process of apoptosis induction by DNA double-strand breaks, providing new insights into the intracellular mechanisms that determine the