The results of a collaborative study with Professor Hiroshi Handa of Tokyo Medical University and Professor Masahiro Kizaki of Saitama Medical University were published in Nature Chemical Biology on September 21. The study revealed that the degradation of a protein called ARID2 is involved in the anticancer effect of pomalidomide, a drug for multiple myeloma, […]
The results of our joint research with Prof. Handa and colleagues at Tokyo Medical University have been published in Scientific Reports. This is the result of a genetic screening to elucidate the mechanism of anticancer activity of thalidomide derivatives against multiple myeloma, and revealed that the subcellular localization of thalidomide target protein cereblon (CRBN) plays
Dr. Junichi Yamamoto has joined as an Assistant Professor at School of Bioscience and Biotechnology on March 1, 2020!
The results of our joint research with Prof. Hidetaka Takahashi and colleagues at Yokohama City University have been published in Nature Communications. This study revealed that a central factor for transcription initiation called Mediator and a transcription elongation factor complex called Little Elongation Complex (LEC) are involved in transcription termination of some genes in a
The results of a collaborative study with Tokyo Medical University and others have been published in Nature Chemical Biology. The study identified p63, a transcription factor of the p53 family, as a novel substrate protein for Cereblon (CRBN) E3 ubiquitin ligase, an intracellular target protein of thalidomide, and found that ubiquitination and degradation of the
The results of our joint research with Professor Hiroshi Handa, Tokyo Medical University, have been published in iScience (a new journal from Cell Press). This study reveals a new function of cereblon (CRBN), an intracellular target protein of thalidomide, using zebrafish as a model organism. CRBN regulates the proliferation of neural stem cells. Since CRBN
Three students joined our lab in April 2019, and we have updated our lab member page.
On April 6, 2019, we held a Cherry Blossom Viewing and New Student Welcome Party on the Suzukakedai Campus.
The results of our joint research with Professor Takaaki Tamura, Graduate School of Science, Chiba University, have been published in Scientific Reports. This study shows that TLP, a member of the TATA box-binding protein family, regulates the process of apoptosis induction by DNA double-strand breaks, providing new insights into the intracellular mechanisms that determine the
