The results of joint research with Professor Hidetaka Takahashi and Assistant Professor Hidefumi Suzuki at Yokohama City University were published in Nature Communications on May 25. This work shows that the Mediator complex of transcription is involved in the transient arrest of Pol II at the 3′ end of replication-dependent histone genes.
The results of a collaborative study with Professor Hiroshi Handa of Tokyo Medical University and Professor Masahiro Kizaki of Saitama Medical University were published in Nature Chemical Biology on September 21. The study revealed that the degradation of a protein called ARID2 is involved in the anticancer effect of pomalidomide, a drug for multiple myeloma,
The results of our joint research with Prof. Handa and colleagues at Tokyo Medical University have been published in Scientific Reports. This is the result of a genetic screening to elucidate the mechanism of anticancer activity of thalidomide derivatives against multiple myeloma, and revealed that the subcellular localization of thalidomide target protein cereblon (CRBN) plays
The results of our joint research with Prof. Hidetaka Takahashi and colleagues at Yokohama City University have been published in Nature Communications. This study revealed that a central factor for transcription initiation called Mediator and a transcription elongation factor complex called Little Elongation Complex (LEC) are involved in transcription termination of some genes in a
The results of a collaborative study with Tokyo Medical University and others have been published in Nature Chemical Biology. The study identified p63, a transcription factor of the p53 family, as a novel substrate protein for Cereblon (CRBN) E3 ubiquitin ligase, an intracellular target protein of thalidomide, and found that ubiquitination and degradation of the
The results of our joint research with Professor Hiroshi Handa, Tokyo Medical University, have been published in iScience (a new journal from Cell Press). This study reveals a new function of cereblon (CRBN), an intracellular target protein of thalidomide, using zebrafish as a model organism. CRBN regulates the proliferation of neural stem cells. Since CRBN
The results of our joint research with Professor Takaaki Tamura, Graduate School of Science, Chiba University, have been published in Scientific Reports. This study shows that TLP, a member of the TATA box-binding protein family, regulates the process of apoptosis induction by DNA double-strand breaks, providing new insights into the intracellular mechanisms that determine the
The results of a collaborative study with Nara Institute of Science and Technology, Tokyo Medical University, and Nagoya Institute of Technology have been published in Scientific Reports. This is a detailed analysis of the binding of thalidomide optical isomers to thalidomide target protein Cereblon (CRBN), revealing differences in pharmacological effects of the optical isomers at
The results of our joint research with Keio University and Tokyo Medical University have been published today in Nature Communications. This is the world’s first elucidation of the unique three-dimensional structure of a protein involved in malignant tumor growth and drug resistance.
The paper “CTCF regulates NELF, DSIF and P-TEFb recruitment during transcription” has been accepted for publication in the transcription journal Transcription. The first author of this paper is Clelia Laitem (University of Oxford, Shona Murphy lab), who visited our lab and collaborated with us as a JSPS Research Fellow two years ago, and the co-authors
